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Hypervalent iodine-mediated Ritter-type amidation of terminal alkenes: The synthesis of isoxazoline and pyrazoline cores
- Park, Sang Won;
- Kim, Soong-Hyun;
- Song, Jaeyoung;
- Park, Ga Young;
- Kim, Darong;
- ... Nam, Tae-Gyu;
- 외 1명
WEB OF SCIENCE
11SCOPUS
12초록
Hypervalent iodine-mediated olefin functionalization provides a rapid gateway towards accessing both various heterocyclic cores and functional groups. In this regard, we have developed a Ritter-type alkene functionalization utilizing a PhI(OAc)(2) ((diacetoxyiodo) benzene, PIDA)/Lewis acid combination in order to access isoxazoline and pyrazoline cores. Based on allyl ketone oximes and allyl ketone tosylhydrazones, we have developed an alkene oxyamidation and amido-amidation protocol en route to accessing both isoxazoline and pyrazoline cores. Additionally, acetonitrile serves as both the solvent and an amine source in the presence of this PIDA/Lewis acid combination. This operationally straightforward and metal-free protocol provides an easy access to isoxazoline and pyrazoline derivatives.
키워드
- 제목
- Hypervalent iodine-mediated Ritter-type amidation of terminal alkenes: The synthesis of isoxazoline and pyrazoline cores
- 저자
- Park, Sang Won; Kim, Soong-Hyun; Song, Jaeyoung; Park, Ga Young; Kim, Darong; Nam, Tae-Gyu; Hong, Ki Bum
- 발행일
- 2018-05
- 유형
- Article
- 권
- 14
- 페이지
- 1028 ~ 1033
- 언어
- ENG
- 출판사
- BEILSTEIN-INSTITUT
- 발행국가
- 독일
- 분량
- 6 페이지
- ISSN
- P 1860-5397