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A small molecule inhibitor of alpha 4 integrin-dependent cell migration
- Lee, Jongkook;
- Hong, Jiyong;
- Nam, Tae-Gyu;
- Peters, Eric C.;
- Orth, Anthony P.;
- 외 5명
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7초록
A small molecule inhibitor of alpha 4 integrin-dependent cell migration was identified through a cell-based screen of small molecule libraries. Biochemical and cellular experiments suggest that this molecule functions by interacting with gamma-parvin. This molecule should serve as a useful tool to study alpha 4 integrin signaling and may lead to new therapeutics for the treatment of autoimmune diseases. (C) 2008 Elsevier Ltd. All rights reserved.
키워드
COTTON-TOP TAMARIN; GAMMA-PARVIN; ANTAGONISTS; ANTIBODY; KINASE; LIBRARIES; COLITIS; BINDING; COTTON-TOP TAMARIN; GAMMA-PARVIN; ANTAGONISTS; ANTIBODY; KINASE; LIBRARIES; COLITIS; BINDING
- 제목
- A small molecule inhibitor of alpha 4 integrin-dependent cell migration
- 저자
- Lee, Jongkook; Hong, Jiyong; Nam, Tae-Gyu; Peters, Eric C.; Orth, Anthony P.; Geierstanger, Bernhard H.; Goldfinger, Lawrence E.; Ginsberg, Mark H.; Cho, Charles Y.; Schultz, Peter G.
- 발행일
- 2009-02
- 유형
- Article
- 권
- 17
- 호
- 3
- 페이지
- 977 ~ 980
- 언어
- ENG
- 출판사
- PERGAMON-ELSEVIER SCIENCE LTD
- 발행국가
- 영국
- 분량
- 4 페이지
- ISSN
- E 1464-3391
P 0968-0896