Synthesis and Characterization of Gallic Acid Mediated Iridium Nanoparticles: Characterizations and Antioxidant Assessments

초록

Having antioxidant properties of nanomaterials plays an important role in developing cosmeceuticals and pharmaceuticals to treat various diseases that occur through reactive oxygen species (ROS). Nanomaterials with enzyme-like properties can suppress ROS, which can be useful for the development of medicinal substances. Recently, transition metal nanoparticles have gained much attention in the development of nanozyme properties, owing to their simple experimental procedure and low-cost production. In this study, we developed gallic acid-mediated iridium nanoparticles (Ir-GA NPs) using the sodium borohydride reduction method and subsequently characterized them using different analytical techniques. The sizes of the Ir-GA NPs were in the nano range. The physicochemical properties of Ir-GA NPs were confirmed by dynamic light scattering analysis (DLS), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), elemental analysis, and high-resolution transmission electron microscopy (TEM). Additionally, the antioxidant activity of the developed Ir-GA NP was evaluated using reactive oxygen species (ROS), and the results supported the significantly compromised intracellular redox conditions. Additionally, CCK-8 and DCFH-DA assays were used to evaluate the biocompatibility and toxicological profile of the produced Ir-GA NPs using the A549 lung cancer cell line. The Ir-GA NPs significantly scavenged ROS. Hence, the developed Ir-GA NPs could act as antioxidants for biological and biomedical applications.

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