Copper sulfide: An emerging adaptable nanoplatform in cancer theranostics

  • Poudel, Kishwor; 
  • Gautam, Milan; 
  • Jin, Sung Giu; 
  • Choi, Han-Gon; 
  • Yong, Chul Soon; 
  • 외 1명
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62
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75

초록

Copper sulfide nanoparticles (CuS NPs), emerging nanoplatforms with dual diagnostic and therapeutic applications, are being actively investigated in this era of "war on cancer" owing to their versatility and adaptability. This article discusses the pros and cons of using CuS NPs in diagnostics, therapeutics, and theranostics. The first section introduces CuS NPs and discusses the features that render them more advantageous than other established nanoplatforms in cancer management. Subsequent sections include specific in vitro and in vivo results of different studies showing the potential of CuS NPs as nanoplatforms. Methods used for visualization (photoacoustic imaging and magnetic resonance imaging) of CuS NPs and treatment (phototherapy and combinatorial therapy) have also been discussed. Furthermore, the challenges and opportunities associated with using CuS NPs have been elucidated. Further investigations on CuS NPs are required to translate it for clinical applications.

키워드

Copper sulfide; Nanoplatforms; Therapeutics; Theranostics; DRUG-DELIVERY SYSTEM; EFFICIENT SYNERGISTIC THERAPY; RADIO-PHOTOTHERMAL THERAPY; IN-VIVO; CUS NANOPARTICLES; PHOTODYNAMIC THERAPY; GOLD NANOPARTICLES; SURFACE MODIFICATION; SHELL NANOPARTICLES; TARGETED DELIVERY
제목
Copper sulfide: An emerging adaptable nanoplatform in cancer theranostics
저자
Poudel, Kishwor; Gautam, Milan; Jin, Sung Giu; Choi, Han-Gon; Yong, Chul Soon; Kim, Jong Oh
DOI
10.1016/j.ijpharm.2019.03.043
발행일
2019-05
유형
Review
저널명
International Journal of Pharmaceutics
권
562
페이지
135 ~ 150