Total synthesis of paecilomycine A

초록

(Chemical Equation Presented) Piecing together paecilomycine: The first total synthesis of paecilomycine A, a terpenoid that enhances nerve growth factor levels in certain human cells, has been achieved. Two highly stereoselective key steps in this concise route include an intermolecular Diels-Alder reaction and an intramolecular Pauson-Khand reaction (see scheme).

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