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A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins
- Chae, Pil Seok;
- Rasmussen, Soren G. F.;
- Rana, Rohini R.;
- Gotfryd, Kamil;
- Kruse, Andrew C.;
- 외 9명
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WEB OF SCIENCE
132Citations
SCOPUS
136초록
Non-traditional amphiphiles: Conferring aqueous solubility on membrane proteins generally requires the use of a detergent or other amphiphilic agent. A new class of amphiphiles was synthesized, based on steroidal lipophilic groups, and evaluated with several membrane proteins. The results show that the new amphiphile, "glyco-diosgenin" (GDN; see figure), confers enhanced stability to a variety of membrane proteins in solution relative to popular conventional detergents, such as dodecylmaltoside (DDM). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
키워드
amphiphiles; membrane proteins; molecular design; solubilization; stabilization; MUSCARINIC ACETYLCHOLINE-RECEPTOR; FACIAL AMPHIPHILES; AQUEOUS-SOLUTIONS; HEMIFLUORINATED SURFACTANTS; BETA(2) ADRENOCEPTOR; STRUCTURAL INSIGHTS; DETERGENT; CHOLESTEROL; AMPHIPOLS; COMPLEX
- 제목
- A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins
- 저자
- Chae, Pil Seok; Rasmussen, Soren G. F.; Rana, Rohini R.; Gotfryd, Kamil; Kruse, Andrew C.; Manglik, Aashish; Cho, Kyung Ho; Nurva, Shailika; Gether, Ulrik; Guan, Lan; Loland, Claus J.; Byrne, Bernadette; Kobilka, Brian K.; Gellman, Samuel H.
- 발행일
- 2012-07
- 유형
- Article
- 권
- 18
- 호
- 31
- 페이지
- 9485 ~ 9490
- 언어
- ENG
- 출판사
- WILEY-V C H VERLAG GMBH
- 발행국가
- 독일
- 분량
- 6 페이지
- ISSN
- P 0947-6539