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Synthesis and Biological Evaluation of 1-Heteroarylmethyl 1,4-Diazepanes Derivatives as Potential T-type Calcium Channel Blockers
- Ullapu, Punna Reddy;
- Ku, Su Jin;
- Choi, Yeon Hee;
- Park, Jiyeon;
- Han, So-Yeop;
- ... Min, Sun-Joon;
- 외 4명
Citations
WEB OF SCIENCE
6Citations
SCOPUS
5초록
The synthesis and biological evaluation of 1-heteroarylmethyl 1,4-diazepane derivatives as potential T-type calcium channel blockers is described. In this study, we have identified the compound 211 exhibiting the most potent T-type calcium channel blocking activity with IC(50) value of 0.20 mu M, which is superior to that of mibefradil.
키워드
T-type calcium channel blockers; 1,4-Diazepanes; Heteroaromatic compounds; FDSS6000 assay; Patch-clamp assay; CA2+ CHANNELS; ANTAGONISTS; INHIBITION; ACID
- 제목
- Synthesis and Biological Evaluation of 1-Heteroarylmethyl 1,4-Diazepanes Derivatives as Potential T-type Calcium Channel Blockers
- 저자
- Ullapu, Punna Reddy; Ku, Su Jin; Choi, Yeon Hee; Park, Jiyeon; Han, So-Yeop; Baek, Du Jong; Lee, Jaekyun; Pae, Ae Nim; Min, Sun-Joon; Cho, Yong Seo
- 발행일
- 2011-08
- 유형
- Article
- 권
- 32
- 호
- 8
- 페이지
- 3063 ~ 3073
- 언어
- ENG
- 출판사
- KOREAN CHEMICAL SOC
- 발행국가
- 대한민국
- 분량
- 11 페이지
- ISSN
- P 0253-2964