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Preparation of Neutron-Activatable Holmium Nanoparticles for the Treatment of Ovarian Cancer Metastases
- Di Pasqua, Anthony J.;
- Huckle, James E.;
- Kim, Jin-Ki;
- Chung, Younjee;
- Wang, Andrew Z.;
- 외 2명
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17Citations
SCOPUS
19초록
Nanoparticles containing stable holmium (165Ho) are prepared by nanotemplate engineering and subsequently irradiated in a neutron flux to yield 166Ho, a beta-emitting radiotherapeutic isotope. After intraperitoneal injection to mice bearing SKOV-3 ovarian tumors, significant tumor accumulation of the 166Ho-nanoparticles is observed by SPECT imaging indicating the potential of these neutron activatable nanoparticles for internal radiation therapy of ovarian cancer metastases.
키워드
drug delivery; holmium; imaging; nanoparticle; ovarian cancer; IN-VITRO; MICROSPHERES; STABILITY; AGENT
- 제목
- Preparation of Neutron-Activatable Holmium Nanoparticles for the Treatment of Ovarian Cancer Metastases
- 저자
- Di Pasqua, Anthony J.; Huckle, James E.; Kim, Jin-Ki; Chung, Younjee; Wang, Andrew Z.; Jay, Michael; Lu, Xiuling
- 발행일
- 2012-04
- 유형
- Article
- 저널명
- Small
- 권
- 8
- 호
- 7
- 페이지
- 997 ~ 1000
- 언어
- ENG
- 출판사
- WILEY-V C H VERLAG GMBH
- 발행국가
- 독일
- 분량
- 4 페이지
- ISSN
- E 1613-6829
P 1613-6810