Reactive Oxygen Species Driven Angiogenesis by Inorganic Nanorods

Patra, Chitta Ranjan; Kim, Jong-Ho; Pramanik, Kallal; d'Uscio, Livius V.; Patra, Sujata; Pal, Krishnendu; Ramchandran, Ramani; Strano, Michael S.; Mukhopadhyay, Debabrata

doi:10.1021/nl2028766

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Reactive Oxygen Species Driven Angiogenesis by Inorganic Nanorods

Patra, Chitta Ranjan;
Kim, Jong-Ho;
Pramanik, Kallal;
d'Uscio, Livius V.;
Patra, Sujata;
외 4명

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79

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83

초록

The exact mechanism of angiogenesis by europium hydroxide nanorods was unclear. In this study we have showed that formation of reactive oxygen species (H2O2 and O-2 center dot-) is involved in redox signaling pathways during angiogenesis, important for cardiovascular and ischemic diseases. Here we used single-walled carbon nanotube sensor array to measure the single-molecule efflux of H2O2 and a HPLC method for the determination of O-2 center dot- from endothelial cells in response to proangiogenic factors. Additionally, reactive oxygen species-mediated angiogenesis using inorganic nanorods was observed in transgenic (flila:EGFP) zebrafish embryos.

키워드

Europium hydroxide [Eu-III(OH)(3)] nanorods; reactive oxygen species; hydrogen peroxide (H2O2); single-walled carbon nanotubes; in vivo angiogenesis; zebrafish model; GROWTH-FACTOR; MOLECULAR-MECHANISMS; CARBON NANOTUBES; TUMOR-GROWTH; FLUORESCENCE; TOXICITY; OXIDANTS; BIOLOGY; H2O2

제목: Reactive Oxygen Species Driven Angiogenesis by Inorganic Nanorods

저자: Patra, Chitta Ranjan; Kim, Jong-Ho; Pramanik, Kallal; d'Uscio, Livius V.; Patra, Sujata; Pal, Krishnendu; Ramchandran, Ramani; Strano, Michael S.; Mukhopadhyay, Debabrata

DOI: 10.1021/nl2028766

발행일: 2011-11

유형: Article

저널명: Nano Letters

권: 11

호: 11

페이지: 4932 ~ 4938

언어: ENG

출판사: AMER CHEMICAL SOC

발행국가: 미국

분량: 7 페이지

ISSN: E 1530-6992
P 1530-6984