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Protective effects of cleavage agents on INS-1 cells against h-IAPP-induced apoptosis
- Jeong, Keunhong;
- Cho, Hye Rim;
- Choi, Seung Hong;
- Park, Yangki;
- Chae, Pil Seok
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6초록
Cleavage agents showed cleavage yields as much as 9-14%, which does not sufficiently support the agents' protection of beta-cells from the cytotoxicity of h-IAPP. INS-1 cell tests were carried out to better understand the potential of using these cleavage agents as drug candidates. This study provides the firm basis for clinical applicability of these cleavage agents.
키워드
IMAGING AGENT; HIGH-AFFINITY; ISLET; CYTOTOXICITY; DERIVATIVES; OLIGOMERS; BINDING; MODEL; MASS
- 제목
- Protective effects of cleavage agents on INS-1 cells against h-IAPP-induced apoptosis
- 저자
- Jeong, Keunhong; Cho, Hye Rim; Choi, Seung Hong; Park, Yangki; Chae, Pil Seok
- 발행일
- 2012-01
- 유형
- Article
- 권
- 48
- 호
- 4
- 페이지
- 588 ~ 590
- 언어
- ENG
- 출판사
- ROYAL SOC CHEMISTRY
- 발행국가
- 영국
- 분량
- 3 페이지
- ISSN
- E 1364-548X
P 1359-7345