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Total Synthesis and Biological Evaluation of Sericetin for Protection against Cisplatin-Induced Acute Kidney Injury
- Kim, Eun-Sun;
- Jang, Hongjun;
- Chang, Sun-Young;
- Baek, Seung-Hoon;
- Bae, Ok-Nam;
- 외 1명
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12초록
A concise synthesis of sericetin (1) was performed in four steps from readily available 3-O-benzylgalangin (4), featuring electrocyclization to produce the tricyclic core and a sequential aromatic Claisen/Cope rearrangement to incorporate the 8-prenyl group of 1. In addition, the therapeutic potential of sericetin (1), isosericetin (2), and three prenylated tetracyclic synthetic intermediates (11, 12, and 14) against cisplatin-induced nephrotoxicity using renal tubular cells were evaluated. Compound 14 showed therapeutic potential against cisplatin-induced kidney damage.
키워드
PRENYLATED FLAVONOIDS; INDUCED NEPHROTOXICITY; OXIDATIVE STRESS; MACAKURZIN C; CELL-DEATH; IN-VITRO; INFLAMMATION; INHIBITION; MECHANISMS; APOPTOSIS; PRENYLATED FLAVONOIDS; INDUCED NEPHROTOXICITY; OXIDATIVE STRESS; MACAKURZIN C; CELL-DEATH; IN-VITRO; INFLAMMATION; INHIBITION; MECHANISMS; APOPTOSIS
- 제목
- Total Synthesis and Biological Evaluation of Sericetin for Protection against Cisplatin-Induced Acute Kidney Injury
- 저자
- Kim, Eun-Sun; Jang, Hongjun; Chang, Sun-Young; Baek, Seung-Hoon; Bae, Ok-Nam; Kim, Hyoungsu
- 발행일
- 2018-12
- 유형
- Article
- 권
- 81
- 호
- 12
- 페이지
- 2647 ~ 2653
- 언어
- ENG
- 출판사
- AMER CHEMICAL SOC
- 발행국가
- 미국
- 분량
- 7 페이지
- ISSN
- E 1520-6025
P 0163-3864