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Thieny/Furanyl-hydroxyphenylpropenones as Inhibitors of LPS-induced ROS and NO Production in RAW 264.7 Macrophages, and Their Structure-Activity Relationship Study
- Kadayat, Tara Man;
- Kim, Mi Jin;
- Nam, Tae-gyu;
- Park, Pil-Hoon;
- Lee, Eung-Seok
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10초록
Twelve thienyl/furanyl-hydroxyphenylpropenones were Systematically designed and synthesized, and evaluated for their inhibitory effect on LPS-induced ROS and NO production in RAW 264.7 macrophages. Compound 11 displayed the most significant inhibitory activity of LPS-induced ROS and NO production in RAW 264.7 macrophages. Structure-activity relationship study indicated that para-hydroxyphenyl moiety plays an important role for inhibitory activities on both LPS-induced ROS and NO production as well as 3-thienyl moiety on molecule.
키워드
Thieny/Furanyl-hydroxyphenylpropenones; LPS-induced ROS and NO; Inhibition; Structure-activity relationship study; NITRIC-OXIDE; SYNTHETIC CHALCONES; OXIDATIVE STRESS; TOPOISOMERASE-I; CELLS; 1-FURAN-2-YL-3-PYRIDIN-2-YL-PROPENONE; HYDROXYCHALCONES; CYTOTOXICITY; PYRIDINES; FLAVONES
- 제목
- Thieny/Furanyl-hydroxyphenylpropenones as Inhibitors of LPS-induced ROS and NO Production in RAW 264.7 Macrophages, and Their Structure-Activity Relationship Study
- 저자
- Kadayat, Tara Man; Kim, Mi Jin; Nam, Tae-gyu; Park, Pil-Hoon; Lee, Eung-Seok
- 발행일
- 2014-08
- 유형
- Article
- 권
- 35
- 호
- 8
- 페이지
- 2481 ~ 2486
- 언어
- ENG
- 출판사
- KOREAN CHEMICAL SOC
- 발행국가
- 대한민국
- 분량
- 6 페이지
- ISSN
- E 1229-5949
P 0253-2964