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Facile synthesis and biological evaluation of 3,3-diphenylpropanoyl piperazines as T-type calcium channel blockers
- Choi, Yeon-hee;
- Baek, Du Jong;
- Seo, Seon Hee;
- Lee, Jae Kyun;
- Pae, Ae Nim;
- ... Min, Sun-Joon;
- 외 1명
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16초록
We have developed a facile synthesis of 3,3-diphenylpropanamides using Meldrum's acid derivatives as amide coupling components. The in vitro biological evaluation of the title compounds led to the identification of compound 1h, which has good inhibitory activity against T-type calcium channel (IC50 = 0.83 mu M). (C) 2010 Elsevier Ltd. All rights reserved.
키워드
T-Type calcium channel blockers; Meldrum's acid; 3,3-Diphenylpropanoyl piperazine; HTS assays; MELDRUMS ACIDS; DERIVATIVES; EFFICIENT; ANALOGS
- 제목
- Facile synthesis and biological evaluation of 3,3-diphenylpropanoyl piperazines as T-type calcium channel blockers
- 저자
- Choi, Yeon-hee; Baek, Du Jong; Seo, Seon Hee; Lee, Jae Kyun; Pae, Ae Nim; Cho, Yong Seo; Min, Sun-Joon
- 발행일
- 2011-01
- 유형
- Article
- 권
- 21
- 호
- 1
- 페이지
- 215 ~ 219
- 언어
- ENG
- 출판사
- PERGAMON-ELSEVIER SCIENCE LTD
- 발행국가
- 영국
- 분량
- 5 페이지
- ISSN
- E 1464-3405
P 0960-894X