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Tracking the establishment of local endemic populations of an emergent enteric pathogen
- Holt, Kathryn E.;
- Tran Vu Thieu Nga;
- Duy Pham Thanh;
- Ha Vinh;
- Kim, Dong Wook;
- 외 25명
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113초록
Shigella sonnei is a human-adapted pathogen that is emerging globally as the dominant agent of bacterial dysentery. To investigate local establishment, we sequenced the genomes of 263 Vietnamese S. sonnei isolated over 15 y. Our data show that S. sonnei was introduced into Vietnam in the 1980s and has undergone localized clonal expansion, punctuated by genomic fixation events through periodic selective sweeps. We uncover geographical spread, spatially restricted frontier populations, and convergent evolution through local gene pool sampling. This work provides a unique, high-resolution insight into the microevolution of a pioneering human pathogen during its establishment in a new host population.
키워드
enteric disease; drug resistance; phylogeography; genomics; SHIGELLA-SONNEI; ESCHERICHIA-COLI; QUINOLONE RESISTANCE; RAST SERVER; SALMONELLA; PLASMID; INFECTIONS; PREVALENCE; EVOLUTION; BURDEN
- 제목
- Tracking the establishment of local endemic populations of an emergent enteric pathogen
- 저자
- Holt, Kathryn E.; Tran Vu Thieu Nga; Duy Pham Thanh; Ha Vinh; Kim, Dong Wook; My Phan Vu Tra; Campbell, James I.; Nguyen Van Minh Hoang; Nguyen Thanh Vinh; Pham Van Minh; Cao Thu Thuy; Tran Thi Thu Nga; Thompson, Corinne; Tran Thi Ngoc Dung; Nguyen Thi Khanh Nhu; Phat Voong Vinh; Pham Thi Ngoc Tuyet; Hoang Le Phuc; Nguyen Thi Nam Lien; Bui Duc Phu; Nguyen Thi Thuy Ai; Nguyen Manh Tien; Nguyen Dong; Parry, Christopher M.; Tran Tinh Hien; Farrar, Jeremy J.; Parkhill, Julian; Dougan, Gordon; Thomson, Nicholas R.; Baker, Stephen
- 발행일
- 2013-10
- 유형
- Article
- 권
- 110
- 호
- 43
- 페이지
- 17522 ~ 17527
- 언어
- ENG
- 출판사
- NATL ACAD SCIENCES
- 발행국가
- 미국
- 분량
- 6 페이지
- ISSN
- P 0027-8424