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Construction of 8-Azabicyclo[3.2.1]octanes via Sequential DDQ-Mediated Oxidative Mannich Reactions of N-Aryl Pyrrolidines
- Jo, Hanbyeol;
- Hassan, Ahmed H. E.;
- Jung, Seung Young;
- Lee, Jae Kyun;
- Cho, Yong Seo;
- ... Min, Sun-Joon
Citations
WEB OF SCIENCE
30Citations
SCOPUS
31초록
A concise synthesis of 8-azabicyclo [3.2.1] octanes via sequential oxidative Mannich reactions is described. This approach involves an intermolecular oxidative Mannich coupling reaction between N-aryl pyrrolidines with TMS enol ether and a subsequent intramolecular oxidative Mannich cyclization of the corresponding silyl enol ether. DDQ is used as a key oxidant for both reactions.
키워드
CATALYTIC ENANTIOSELECTIVE SYNTHESIS; DEHYDROGENATIVE COUPLING REACTIONS; BOND-FORMING REACTIONS; C-H FUNCTIONALIZATION; TROPANE ALKALOIDS; ASYMMETRIC-SYNTHESIS; TERTIARY-AMINES; AEROBIC CONDITIONS; DERIVATIVES; PHOTOREDOX; CATALYTIC ENANTIOSELECTIVE SYNTHESIS; DEHYDROGENATIVE COUPLING REACTIONS; TROPANE ALKALOIDS; C-C; ASYMMETRIC-SYNTHESIS; BOND FORMATION; FUNCTIONALIZED TROPANES; PHOTOREDOX; AMINES; DERIVATIVES
- 제목
- Construction of 8-Azabicyclo[3.2.1]octanes via Sequential DDQ-Mediated Oxidative Mannich Reactions of N-Aryl Pyrrolidines
- 저자
- Jo, Hanbyeol; Hassan, Ahmed H. E.; Jung, Seung Young; Lee, Jae Kyun; Cho, Yong Seo; Min, Sun-Joon
- 발행일
- 2018-02
- 유형
- Article
- 저널명
- Organic Letters
- 권
- 20
- 호
- 4
- 페이지
- 1175 ~ 1178
- 언어
- ENG
- 출판사
- AMER CHEMICAL SOC
- 발행국가
- 미국
- 분량
- 4 페이지
- ISSN
- E 1523-7052
P 1523-7060