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Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation
- Bae, Hyoung Eun;
- Mortensen, Jonas S.;
- Ribeiro, Orquidea;
- Du, Yang;
- Ehsan, Muhammad;
- ... Chae, Pil Seok;
- 외 3명
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14초록
A novel class of detergents, designated tandem neopentyl glycol maltosides (TNMs), were evaluated with four target membrane proteins. The best detergent varied depending on the target, but TNM-C12L and TNM-C11S were notable for their ability to confer increased membrane protein stability compared to DDM. These agents have potential for use in membrane protein research.
키워드
FACIAL AMPHIPHILES; DETERGENT; CRYSTALLIZATION; TRANSPORT; RECEPTOR; CRYSTALLOGRAPHY; SOLUBILIZATION; SURFACTANTS; EXPRESSION; INSIGHTS
- 제목
- Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation
- 저자
- Bae, Hyoung Eun; Mortensen, Jonas S.; Ribeiro, Orquidea; Du, Yang; Ehsan, Muhammad; Kobilka, Brian K.; Loland, Claus J.; Byrne, Bernadette; Chae, Pil Seok
- 발행일
- 2016-00
- 유형
- Article
- 권
- 52
- 호
- 81
- 페이지
- 12104 ~ 12107
- 언어
- ENG
- 출판사
- ROYAL SOC CHEMISTRY
- 발행국가
- 영국
- 분량
- 4 페이지
- ISSN
- E 1364-548X
P 1359-7345