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Effect of alpha-resorcylic acid-L-phenylalanine amide on collagen synthesis and matrix metalloproteinase expression in fibroblasts
- Kwak, Seon-Yeong;
- Noh, Jin-Mi;
- Lee, Suyeon;
- Lee, So Hun;
- Jeon, Su-ji;
- ... Kim, Jong-Ho;
- 외 2명
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4초록
Regulation of collagen synthesis and matrix metalloproteinases (MMPs) expression levels has been an important issue in medicinal, pharmaceutical and cosmetic industries. Herein, alpha-Resorcylic acid-phenylalanine amide (alpha-RA-F) was prepared and its biological activities were observed. We found that alpha-RA-F boosted collagen synthesis and reduced MMPs expression levels in human fibroblasts without cytotoxicity. (C) 2014 Elsevier Ltd. All rights reserved.
키워드
Resorcylic acid derivative; Collagen synthesis; Suppression of MMPs expression; MECHANISMS; ACTIVATION
- 제목
- Effect of alpha-resorcylic acid-L-phenylalanine amide on collagen synthesis and matrix metalloproteinase expression in fibroblasts
- 저자
- Kwak, Seon-Yeong; Noh, Jin-Mi; Lee, Suyeon; Lee, So Hun; Jeon, Su-ji; Kim, Hye-In; Kim, Jong-Ho; Lee, Yoon-Sik
- 발행일
- 2014-02
- 유형
- Article
- 권
- 24
- 호
- 3
- 페이지
- 742 ~ 745
- 언어
- ENG
- 출판사
- PERGAMON-ELSEVIER SCIENCE LTD
- 발행국가
- 영국
- 분량
- 4 페이지
- ISSN
- E 1464-3405
P 0960-894X