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Identification and Characterization of Small-Molecule Inducers of Fetal Hemoglobin
- Nam, Tae-gyu;
- Lee, Jongkook;
- Walker, John R.;
- Brinker, Achim;
- Cho, Charles Y.;
- 외 1명
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WEB OF SCIENCE
6Citations
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6초록
Induction of γ-globin, a component of fetal hemoglobin (HbF, α2γ2), represents one therapeutic strategy to ameliorate the pathological symptoms of sickle cell disease. A high-throughput screen of a large chemical library identified a 2,6-diamino-substituted purine, TN1, which induces HbF more potently than hydroxyurea in KU812 and K562 leukemia cell lines.
키워드
fetal hemoglobin; high-throughput screening; sickle cell disease; STAT3; SICKLE-CELL-DISEASE; GAMMA-GLOBIN GENE; ERYTHROID PROGENITORS; IN-VITRO; INDUCTION; HYDROXYUREA; EXPRESSION; MECHANISM; BCL11A; BLOOD
- 제목
- Identification and Characterization of Small-Molecule Inducers of Fetal Hemoglobin
- 저자
- Nam, Tae-gyu; Lee, Jongkook; Walker, John R.; Brinker, Achim; Cho, Charles Y.; Schultz, Peter G.
- 발행일
- 2011-05
- 유형
- Article
- 저널명
- ChemMedChem
- 권
- 6
- 호
- 5
- 페이지
- 777 ~ 780
- 언어
- ENG
- 출판사
- WILEY-BLACKWELL
- 발행국가
- 미국
- 분량
- 4 페이지
- ISSN
- P 1860-7179