Porous Three-Dimensional PVA/Gelatin Sponge for Skin Tissue Engineering

  • Choi, Soon Mo; 
  • Singh, Deepti; 
  • Kumar, Ashok; 
  • Oh, Tae Hwan; 
  • Cho, Yong Woo; 
  • 외 1명
Citations

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SCOPUS

79

초록

A series of PVA/gelatin scaffolds in different concentrations were prepared and blended to evaluate the polymer concentration effects on the architecture of the scaffold. SEM images revealed that with increasing gelatin concentration the average pore diameters varied from 60 to 190nm. Bio-compatibility assay showed cells attached and elongated actively on the scaffolds and cyto-toxicity results of all samples were found to be in grade 1 or 0, indicating the bio-safety of PVA/gelatin as biomaterial. Results indicate the polymer concentration effects on the architecture of the scaffold and PVA/gelatin macroporous scaffolds have potential to be bio-matrices for tissue genesis.

키워드

Compression; 3-D sponge; freeze-drying; gelatin; human fibroblast; PVA; skin tissue engineering
제목
Porous Three-Dimensional PVA/Gelatin Sponge for Skin Tissue Engineering
저자
Choi, Soon Mo; Singh, Deepti; Kumar, Ashok; Oh, Tae Hwan; Cho, Yong Woo; Han, Sung Soo
DOI
10.1080/00914037.2012.710862
발행일
2013-03
유형
Article
저널명
International Journal of Polymeric Materials and Polymeric Biomaterials
권
62
호
7
페이지
384 ~ 389