상세 보기
Cleavage agents for soluble oligomers of amyloid beta peptides
- Suh, Junghun;
- Yoo, Sang Ho;
- Kim, Min Gyum;
- Jeong, Keunhong;
- Ahn, Jae Young;
- ... Chae, Pil Seok;
- 외 6명
Citations
WEB OF SCIENCE
104Citations
SCOPUS
111초록
(Chemical Equation Presented) Clearing the mind: Peptide-cleaving agents for amyloid β-42 (Aβ42) oligomers (see scheme), the intermediate neurotoxic species in the pathology of Alzheimer's disease, have been obtained from a combinatorial library built using the CoIII complex of 1,4,7,10-tetraazacyclododecane as the reaction center. Effective cleavage of the Aβ42 oligomers occurs at submicromolar concentrations of the agents. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
키워드
Alzheimer's disease; amyloid beta peptides; combinatorial chemistry; drug design; peptide cleavage; PROTEIN A-BETA; ALZHEIMERS-DISEASE; IN-VIVO; BRAIN; HYPOTHESIS; A-BETA-40
- 제목
- Cleavage agents for soluble oligomers of amyloid beta peptides
- 저자
- Suh, Junghun; Yoo, Sang Ho; Kim, Min Gyum; Jeong, Keunhong; Ahn, Jae Young; Kim, Myoung-Soon; Chae, Pil Seok; Lee, Tae Yeon; Lee, Jaehwa; Lee, Jeongkuk; Jang, Yun Ah; Ko, Eun Hwa
- 발행일
- 2007-00
- 유형
- Article
- 권
- 46
- 호
- 37
- 페이지
- 7064 ~ 7067
- 언어
- ENG
- 출판사
- WILEY-V C H VERLAG GMBH
- 발행국가
- 독일
- 분량
- 4 페이지
- ISSN
- E 1521-3773
P 1433-7851