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The Polyoma Virus Large T Binding Protein p150 Is a Transcriptional Repressor of c-MYC
- Sung, C.K.;
- Yim, H.;
- Gu, H.;
- Li, D.;
- Andrews, E.;
- 외 4명
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20Citations
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19초록
p150, product of the SALL2 gene, is a binding partner of the polyoma virus large T antigen and a putative tumor suppressor. p150 binds to the nuclease hypersensitive element of the c-MYC promoter and represses c-MYC transcription. Overexpression of p150 in human ovarian surface epithelial cells leads to decreased expression, and downregulation to increased expression, of c-MYC. c-MYC is repressed upon restoration of p150 to ovarian carcinoma cells. Induction of apoptosis by etoposide results in recruitment of p150 to the c-MYC promoter and to repression of c-MYC. Analysis of data in The Cancer Genome Atlas shows negative correlations between SALL2 and c-MYC expression in four common solid tumor types. © 2012 Sung et al.
키워드
unclassified drug; transcription regulation; Antineoplastic Agents, Phytogenic; protein p 150; Proto-Oncogene Proteins c-myc; Humans; epithelium cell; Gene Expression Regulation, Neoplastic; solid tumor; Molecular Sequence Data; apoptosis; Myc protein; ca; binding protein; etoposide; Myc protein; protein p 150; unclassified drug; virus large T antigen; apoptosis; article; cancer cell; cancer classification; cancer genetics; cancer inhibition; controlled study; down regulation; epithelium cell; female; gene; gene repression; genetic correlation; human; human cell; nonhuman; ovary; ovary cancer; promoter region; protein analysis; protein binding; protein expression; SALL2 gene; solid tumor; transcription regulation; Antineoplastic Agents, Phytogenic; Base Sequence; Cell Line, Tumor; Etoposide; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Molecular Sequence Data; Neoplasms; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins c-myc; Transcription Factors; Transcription, Genetic; Polyomavirus
- 제목
- The Polyoma Virus Large T Binding Protein p150 Is a Transcriptional Repressor of c-MYC
- 저자
- Sung, C.K.; Yim, H.; Gu, H.; Li, D.; Andrews, E.; Duraisamy, S.; Li, C.; Drapkin, R.; Benjamin, T.
- 발행일
- 2012-09
- 유형
- Article
- 저널명
- PLoS One
- 권
- 7
- 호
- 9
- 페이지
- 1 ~ 7
- 언어
- ENG
- 출판사
- Public Library of Science
- 발행국가
- 미국
- 분량
- 7 페이지
- ISSN
- E 1932-6203
P 1932-6203